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Journal of Allergy and Clinical Immunology
- Source :
- Repositório Institucional da UFBA, Universidade Federal da Bahia (UFBA), instacron:UFBA
- Publication Year :
- 2013
- Publisher :
- Journal of Allergy and Clinical Immunology, 2013.
-
Abstract
- p. 1683–1690 Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-11-05T19:26:40Z No. of bitstreams: 1 444444.pdf: 531518 bytes, checksum: 23bd26ca6af7f62200747ca0bd23ae14 (MD5) Made available in DSpace on 2013-11-05T19:26:40Z (GMT). No. of bitstreams: 1 444444.pdf: 531518 bytes, checksum: 23bd26ca6af7f62200747ca0bd23ae14 (MD5) Previous issue date: 2013 Background Helminth infections are associated with protection against allergies. It is postulated that IL-10 production after helminth infection suppresses skin hypersensitivity and increases IgG4 production, protecting against allergies. Objective We aimed to determine whether IL10 polymorphisms are associated with helminth infection and the risk of wheeze and allergy. Methods Twelve IL10 single nucleotide polymorphisms were genotyped in 1353 children aged 4 to 11 years living in a poor urban area in Salvador, Brazil. Wheezing status, Ascaris lumbricoides and Trichuris trichiura infection, IL-10 production by peripheral blood leukocytes stimulated with A lumbricoides extract, serum total IgE levels, specific IgE levels, skin prick test responses to common aeroallergens, and IgG4 and IgE anti–A lumbricoides antibody levels were measured in all children. Association tests were performed by using logistic or linear regression when appropriate, including sex, age, helminth infection, and principal components for ancestry informative markers as covariates by using PLINK. Results Allele G of marker rs3024496 was associated with the decreased production of IL-10 by peripheral blood leukocytes in response to A lumbricoides stimulation. Allele C of marker rs3024498 was negatively associated with helminth infection or its markers. Marker rs3024492 was positively associated with the risk of atopic wheeze, total IgE levels, and skin prick test responses to cockroach. Conclusions Our findings suggest that IL10 polymorphisms might play a role in the production of IL-10, helminth infection, and allergy. We hypothesize that polymorphisms related to protection against helminths, which would offer an evolutionary advantage to subjects in the past, might be associated with increased risk of allergic diseases. Salvador
Details
- Language :
- English
- ISSN :
- 62200747
- Database :
- OpenAIRE
- Journal :
- Repositório Institucional da UFBA, Universidade Federal da Bahia (UFBA), instacron:UFBA
- Accession number :
- edsair.od......3056..c505dc462a5f8fbbfe73e7c2c65382c5