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Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting sex- and age-related behavioral and immune/neurotrophic alterations in mice : relevance to autism spectrum disorders
- Source :
- Repositório Institucional da Universidade Federal do Ceará (UFC), Universidade Federal do Ceará (UFC), instacron:UFC
- Publication Year :
- 2017
- Publisher :
- Molecular Neurobiology, 2017.
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Abstract
- Early-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic factor—BDNF) alterations were determined in the prefrontal cortex (PFC), hippocampus (HC), and hypothalamus (HT). Since the incidence and clinical manifestations of neurodevelopmental disorders present significant sex-related differences, we sought to distinctly evaluate male and female mice. While on PN35, LPS-challenged male mice presented depressive, anxiety-like, repetitive behavior, and working memory deficits; on PN70, only depressive- and anxiety-like behaviors were observed. Conversely, females presented
- Subjects :
- Autismo
Caracteres Sexuais
Sex Differences
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Repositório Institucional da Universidade Federal do Ceará (UFC), Universidade Federal do Ceará (UFC), instacron:UFC
- Accession number :
- edsair.od......3056..d816ee5ac431df8fcf720a62f96f9138