Niveles de TNF-alfa plasmático en mujeres embarazadas con infección por el virus Zika (ZIKV) y su relación con la gravedad del síndrome congénito: revisión sistemática y metanálisis

The pathological process caused by the Zika virus (ZIKV), which is transmitted by mosquitoes of the Aedes genus, presents different signs and symptoms, with some difficulty in finding genetic, biochemical or immunological biomarkers, indicating alterations at the level of target tissues. Thus, the study aims to verify whether the increased expression or plasma levels of TNF-alpha in pregnant women with ZIKV infection are associated with the occurrence/severity of the Congenital Syndrome. As a methodological process, it is a systematic literature review, following the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol for systematic reviews and meta-analysis. The studies were searched in the Scielo, Pubmed, LILACS and Scopus data sources, where all analyzes were performed using the REVMAN 5.4 software (The Cochrane Collaboration, 2020). Due to the heterogeneity of the studies included in the meta-analysis, the random-effects model was selected, and seven studies were used. The results and discussion indicate that the findings in the studies indicated high I2 values ​​(95%; p