The Proteoglycan Syndecan 4 Regulates Transient Receptor Potential Canonical 6 Channels via RhoA/ROCK Signaling

Authors :: Liu, Ying
Echtermeyer, Frank
Thilo, Florian
Theilmeier, Gregor
Schmidt, Antje
Schülein, Ralf
Jensen, Boye L
Loddenkemper, Christoph
Jankowski, Vera
Marcussen, Niels
Gollasch, Maik
Arendshorst, William J
Tepel, Martin
Source :: Liu, Y, Echtermeyer, F, Thilo, F, Theilmeier, G, Schmidt, A, Schülein, R, Jensen, B L, Loddenkemper, C, Jankowski, V, Marcussen, N, Gollasch, M, Arendshorst, W J & Tepel, M 2012, ' The Proteoglycan Syndecan 4 Regulates Transient Receptor Potential Canonical 6 Channels via RhoA/ROCK Signaling ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, pp. 378-385 . https://doi.org/10.1161/ATVBAHA.111.241018
Publication Year :: 2012
Abstract: OBJECTIVE: Syndecan 4 (Sdc4) modulates signal transduction and regulates activity of protein channels. Sdc4 is essential for the regulation of cellular permeability. We hypothesized that Sdc4 may regulate transient receptor potential canonical 6 (TRPC6) channels, a determinant of glomerular permeability, in a RhoA/ROCK-dependent manner. METHODS AND RESULTS: Sdc4 knockout (Sdc4(-/-)) mice showed increased glomerular filtration rate and ameliorated albuminuria under baseline conditions and after bovine serum albumin overload (each P

Language :: English
Database :: OpenAIRE
Journal :: Liu, Y, Echtermeyer, F, Thilo, F, Theilmeier, G, Schmidt, A, Schülein, R, Jensen, B L, Loddenkemper, C, Jankowski, V, Marcussen, N, Gollasch, M, Arendshorst, W J & Tepel, M 2012, ' The Proteoglycan Syndecan 4 Regulates Transient Receptor Potential Canonical 6 Channels via RhoA/ROCK Signaling ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, pp. 378-385 . https://doi.org/10.1161/ATVBAHA.111.241018
Accession number :: edsair.od......3062..84fcd66b1884160cb708dd133b20c7c7

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