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The regulation of vascular endothelial growth factor by hypoxia and prostaglandin F₂α during human endometrial repair

Authors :
Maybin, Jacqueline A
Hirani, Nikhil
Brown, Pamela
Jabbour, Henry N
Critchley, Hilary O D
Source :
Maybin, J A, Hirani, N, Brown, P, Jabbour, H N & Critchley, H O D 2011, ' The regulation of vascular endothelial growth factor by hypoxia and prostaglandin F₂α during human endometrial repair ', Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 8, pp. 2475-83 . https://doi.org/10.1210/jc.2010-2971
Publication Year :
2011

Abstract

The human endometrium has an exceptional capacity for repeated repair after menses, but its regulation remains undefined. Premenstrually, progesterone levels fall and prostaglandin (PG) F₂α synthesis increases, causing spiral arteriole constriction. We hypothesized that progesterone withdrawal, PGF₂α, and hypoxia increase vascular endothelial growth factor (VEGF), an endometrial repair factor.

Details

Language :
English
Database :
OpenAIRE
Journal :
Maybin, J A, Hirani, N, Brown, P, Jabbour, H N & Critchley, H O D 2011, ' The regulation of vascular endothelial growth factor by hypoxia and prostaglandin F₂α during human endometrial repair ', Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 8, pp. 2475-83 . https://doi.org/10.1210/jc.2010-2971
Accession number :
edsair.od......3094..2d0072435aade55cd227a17f2b93c431