Assessment of effects of thyrotoxicosis on gallstone formation in rabbits [Tavşanlarda Tirotoksikozun Safra Taşı Oluşumu Üzerine Etkilerinin Değerlendirilmesi]

Aim: The etiopathogenesis of gallstone formation is well known, but only a few studies have investigated the effects of thyrotoxicosis on gallstone formation. In this study, we investigated the contribution of thyrotoxicosis to gallstone formation in rabbits. Methods: Forty-four New Zealand rabbits were used. The rabbits were divided into six groups, with each group receiving a different diet. At the end of seven weeks, all rabbits were sacrificed, blood was collected for analysis, and cholecystectomy was performed. Results: Serum levels of both free triiodothyronine (FT3) and thyroxine (FT4) were significantly higher in rabbits receiving thyroid hormone (p0.05). Conclusions: Thyrotoxicosis promotes an increase in gallstone formation risk as a result of an increased bile CSI and gallbladder mucosal inflammation. © 2019 by The Medical Bulletin of University.