Inflammation induced liver damage caused by viral infection or abberant metabolism

With more than 800 000 new cases per year, hepatocellular carcinoma (HCC) is the sixth most common type of cancer and the third most frequent cause of cancer related death. The main drivers for development of HCC are viral infections and Non-alcoholic fatty liver disease (NAFLD), both mediating chronic inflammation and liver damage. In the present thesis I investigated new treatment options (cellular and compound-based) for chronic viral liver infection and the molecular underpinnings in the progression from NAFLD to non-alcoholic steatohepatitis (NASH) and HCC.