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acid phenethyl ester on alveolar bone loss and oxidative stress in

Authors :
Kizildag, A
Arabaci, T
Albayrak, M
Balseven, HM
Kizildag, CA
Tasdemir, U
Publication Year :
2020
Publisher :
TAYLOR & FRANCIS LTD, 2020.

Abstract

Caffeic acid phenethyl ester (CAPE) is used as a therapeutic agent to prevent bone loss. We determined the effects of systemically administered CAPE on alveolar bone loss and oxidative stress in diabetic rats with experimental periodontitis. Forty male rats were divided into four equal groups: control, experimental periodontitis (EP), EP-diabetes mellitus (EP-DM) and EP-DM-CAPE. DM was induced by streptozotocin, then lipopolysaccharide was injected to induce periodontitis. CAPE was administered to the EP-DM-CAPE group daily for 15 days. Then, serum samples were taken and the rats were sacrificed for histological analyses. Serum interleukin (IL-1 beta) and oxidative stress also were evaluated. Alveolar bone loss was assessed histomorphometrically. Alveolar bone loss and IL-1 beta levels were significantly less in the EP-DM-CAPE and EP groups compared to the EP-DM group. Oxidative stress was significantly less in the EP-DM-CAPE group compared to the EP and EP-DM groups. Receptor activator of nuclear factor kappa-B ligand (RANKL) levels were significantly higher in the EP-DM group compared to the disease groups. CAPE significantly reduced RANKL levels in the EP-DM-CAPE group compared to the EP-DM group. We found that CAPE treatment significantly inhibited DM induced oxidative stress and RANKL induced osteoclastogenesis and alveolar bone loss in diabetic rats with periodontitis. C1 [Kizildag, Alper; Balseven, Havva Muge] Pamukkale Univ, Fac Dent, Dept Periodontol, TR-20070 Denizli, Turkey. [Arabaci, Taner] Ataturk Univ, Fac Dent, Dept Periodontol, Erzurum, Turkey. [Albayrak, Mevlut] Ataturk Univ, Hlth Serv Vocat Training Sch, Med Lab Dept, Erzurum, Turkey. [Kizildag, Canan Aksu] Pamukkale Univ, Fac Dent, Dept Orthodont, Denizli, Turkey. [Tasdemir, Ufuk] Pamukkale Univ, Fac Dent, Dept Maxillofacial Surg, Denizli, Turkey.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.od......3566..a97ca562f3b90ccb1fcfb0e6a3e166b0