Can perfusion sensitized MR diffusion weighted imaging discriminate between benign and malignant nodes for patients with head and neck squamous cell carcinoma?

Objective: To investigate fast (perfusion sensitized) and slow (true diffusion sensitized) apparent diffusion coefficient (ADC) measurements as discriminators of benign from malignant lymph nodes in patients with head and neck (H&N) squamous cell carcinoma (SCC). Materials and Methods: Seventeen patients with H&N SCC staged for nodal disease using anatomical MRI, contrast enhanced CT and ultrasound ± fine needle aspiration gave informed consent for additional MR diffusion weighted imaging (DWI). Axial DWI was performed by short tau inversion recovery (STIR) echo planar imaging and trace weighted images obtained b 0, 50, 100, 300, 600 and 1000. Apparent diffusion coefficient (ADC) was calculated by mono-­‐exponential fitting from non-­‐necrotic sections of abnormal and contralateral normal nodes using all 6 b-­‐values (ADC6b); b0-­‐50-­‐100 (ADCfast) and b300-­‐600-­‐1000 (ADCslow). Values were compared between abnormal and normal nodes using the Mann Whitney test. The ability of ADC measures for differentiation between benign and malignant nodes was compared using receiver operating characteristic (ROC) area under curve (AUC) analysis. Results: Median ADC6b, ADCfast and ADCslow for normal nodes was 0.97, 2.19 and 0.73x10-­‐ 3mm2s-­‐1 respectively. Correspondingly median ADC6b, ADCfast and ADCslow for abnormal nodes was 0.91, 1.54 and 0.81x10-­‐3mm2s-­‐1. There was a significant difference of ADCfast (p=0.003) but not for ADC6b (p=0.290) or ADCslow (p=0.493) between normal and abnormal tissue. ROC AUC was 0.62, 0.82 and 0.57 for ADC6b, ADCfast and ADCslow respectively. An ADCfast threshold of