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3D domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase
- Publication Year :
- 2013
-
Abstract
- The intriguing crystal organization of the domain-swapped dimer of a human pancreatic ribonuclease variant indicates that the protein can form fibrils in solution. They were observed and characterized by atomic force microscopy. The importance of domain swapping in inducing native-like fibril formation is highlighted.
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.od......3730..e0ea9c0fe1df5115f803ecb42aa95d0f