Alkylation of rhodanine derivatives with halogenated coumarins

Kumarin i njegovi derivati su važna skupina bioaktivnih heterocikličkih spojeva koji su prisutni u različitim biljnim vrstama. Upravo je biološka aktivnost razlog iznalaženja novih puteva i metoda njihove sinteze. U posljednje vrijeme osobito su značajna otkrića na području zelene kemije i sinteze pa je stoga u ovom radu za sintezu spojeva korišteno „zeleno otapalo“, odnosno eutektičko otapalo (kolin-klorid:urea), koje predstavlja ekološki prihvatljivu verziju organskim otapalima. U ovom je radu opisan postupak alkiliranja derivata rodanina s 3-(bromacetil)-2H-kromen-2-onom u navedenom eutektičkom otapalu, uz K2CO3 kao katalizator. Svi su spojevi potvrđeni LC-MS/MS spektroskopijom te okarakterizirani Rf vrijednostima i temperaturama tališta. Coumarin and its derivates are an important group of heterocylic compounds which are found in various plants exhibiting a wide variety of biological activities. Their potent biological activity is the main reason for finding new methods for their synthesis. In the last few decades, many achievements have been made in the field of green chemistry. Therefore, in this work coumarin derivates were synthesized using deep eutectic solvent (choline-chloride:urea), which are ecologically acceptable compared to conventional organic solvents. This work describes alkylation of rhodanine derivates with 3-(bromoacetyl)-2H-chromen-2-one in solvent with K2CO3 as a catalyst. Structures of all compounds were confirmed by LC-MS/MS spectroscopy and compounds were characterized by Rf values and melting points.