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Brain-derived neurotrophic factor, stress and depression: A minireview
- Publication Year :
- 2009
- Publisher :
- Pergamon-Elsevier Science, 2009.
-
Abstract
- Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family, and is widely expressed in the adult mammalian brain. Besides its well known neuroprotective activity after traumatic brain injury the evidences regarding its activity dependent release by the pathophysiology of major depression are rapidly replicating. Considering the data that stress plays an important role by the development of depression which is characterized with prominent hippocampal cell death, as well as the well known neuroprotective effects of BDNF, we aimed to investigate the link between the BDNF, stress and depression. Thus we prepared a minireview in order to evaluate the neuroprotective role of BDNF by psychiatric disorders which are characterized with prominent neuronal cell death.
- Subjects :
- Serum
Cell death
Survival
Protein bcl 2
Bipolar disorder
Genetic predisposition to disease
Brain Derived Neurotrophic Factor
Electroconvulsive Therapy
Schizophrenia
Review
Neurosciences & neurology
Brain-derived neurotrophic factor
Neuroprotective agents
Association
Depressive disorder, major
Glucocorticoid
Val66met polymorphism
Stress, physiological
Animals
Humans
Nerve cell necrosis
Brain derived neurotrophic factor
Brain nerve cell
Priority journal
Neurons
Genetic risk
N methyl dextro aspartic acid receptor
Depression
Neurosciences
Nonhuman
Hippocampal volume
Neuroprotection
Single nucleotide polymorphism
Mental stress
BDNF
Messenger-rna
Mineralocorticoid
Human-memory
Differentiation
Protein structure
Cognitive defect
Factor bdnf
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.od......9458..5c6e300d7eae23ce533c29d6f8f7dff8