The effects of nettle herb (Urtica dioica l.) on the levels of trace elements in the rabbit fur treates with 7,12-dimetylbenzanthracene Urtica dioica L. (Isırgan Otu)'nin Metanol ve Su Ekstraktının 7,12-dimetilbenz(a)antrasen Uygulanan Tavşan Tüylerindeki İz Element Seviyeleri Üzerine Etkileri

In this study the effect of nettle herb (Urtica dioica L.) on the levels of trace element (Zn, Cu, Mn, Fe) in the rabbit fur treated with 7,12-dimetylbenzanthracene (DMBA) were investigated. The rabbit were divided into three experimental groups and one control group, each group contained seven rabbits. DMBA (0.5 ml/kg/day) were administreated IM to group A as carcinogenic compound. DMBA (0.5 ml/kg/day) were administreated IM as carcinogenic compound plus methanol extract of nettle herb (0.2 ml/kg/day) to group B, DMBA (0.5 ml/kg/day) were administreated IM as carcinogenic compound plus water extract of nettle herb (0.5 ml/kg/day) to group C and 10% dimethylsulphoxide (0.5 ml/kg/day) dissolved in normal saline solution were administrated to control group. All of the treatments were performed for five mounths to each group. The decrases in Cu levels were significant when compared with that of control group (P