[In vitro and in vivo physicochemical study of depot formation of cinchocaine in an atelocollagen matrix]

The paper presents an introductory physicochemical study dealing with the preparation of atelocollagen felt saturated with local anesthetics, with the modelling of the release of the anesthetic from the collagen matrix in vitro, and with the checking of the corresponding analytical procedures (dc-polarography and UV-VIS spectrophotometry) for the determination of cinchocaine. The study is supplemented with experiments in vivo that confirm the usability of the new material for the depot formation of local anesthetics.