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Development of a database and processing method for detecting hematotoxicity adverse drug events
- Source :
- Studies in health technology and informatics. 210
- Publication Year :
- 2015
-
Abstract
- Adverse events are detected by monitoring the patient's status, including blood test results. However, it is difficult to identify all adverse events based on recognition by individual doctors. We developed a system that can be used to detect hematotoxicity adverse events according to blood test results recorded in an electronic medical record system. The blood test results were graded based on Common Terminology Criteria for Adverse Events (CTCAE) and changes in the blood test results (Up, Down, Flat) were assessed according to the variation in the grade. The changes in the blood test and injection data were stored in a database. By comparing the date of injection and start and end dates of the change in the blood test results, adverse events related to a designated drug were detected. Using this method, we searched for the occurrence of serious adverse events (CTCAE Grades 3 or 4) concerning WBC, ALT and creatinine related to paclitaxel at Osaka University Hospital. The rate of occurrence of a decreased WBC count, increased ALT level and increased creatinine level was 36.0%, 0.6% and 0.4%, respectively. This method is useful for detecting and estimating the rate of occurrence of hematotoxicity adverse drug events.
- Subjects :
- Drug-Related Side Effects and Adverse Reactions
Databases, Pharmaceutical
Information Storage and Retrieval
Reproducibility of Results
Decision Support Systems, Clinical
Sensitivity and Specificity
Japan
Risk Factors
Prevalence
Adverse Drug Reaction Reporting Systems
Database Management Systems
Electronic Health Records
Humans
Biomarkers
Subjects
Details
- ISSN :
- 18798365
- Volume :
- 210
- Database :
- OpenAIRE
- Journal :
- Studies in health technology and informatics
- Accession number :
- edsair.pmid..........095f20c91876f86620d9df4070ea33f9