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Review of Neuromyelitis Optica Spectrum Disorder with Pain-Depression Comorbidity

Authors :
Xue, Zhang
Yan, Xu
Li-Jian, Pei
Source :
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. 36(4)
Publication Year :
2022

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disorder of the central nervous system predominantly targeting optic nerves and the spinal cord. The prevalence of the disease is much higher in Asia than in other parts of the world. Pain can be detected in more than 80% of NMOSD patients, with evoked pain mostly being caused by painful tonic muscle spasms and neuropathic pain as the most characteristic types. Depression is often comorbid with pain, and their comorbidity can severely influence quality of life. In recent years, studies have found considerable overlaps between the mechanisms of pain and depression; however, their association remains unclear. This article reviews the epidemiology, mechanism, evaluation and treatment of pain-depression comorbidity in NMOSD patients.

Details

ISSN :
10019294
Volume :
36
Issue :
4
Database :
OpenAIRE
Journal :
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
Accession number :
edsair.pmid..........0acb469769bfdbbb2be7a44dbe7cb01f