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Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

Authors :
Lotta, Luca A.
Pietzner, Maik
Stewart, Isobel D.
Wittemans, Laura B.L.
Li, Chen
Bonelli, Roberto
Raffler, Johannes
Biggs, Emma K.
Oliver-Williams, Clare
Auyeung, Victoria P.W.
Luan, Jian’an
Wheeler, Eleanor
Paige, Ellie
Surendran, Praveen
Michelotti, Gregory A.
Scott, Robert A.
Burgess, Stephen
Zuber, Verena
Sanderson, Eleanor
Koulman, Albert
Imamura, Fumiaki
Forouhi, Nita G.
Khaw, Kay-Tee
Griffin, Julian L.
Wood, Angela M.
Kastenmüller, Gabi
Danesh, John
Butterworth, Adam S.
Gribble, Fiona M.
Reimann, Frank
Bahlo, Melanie
Fauman, Eric
Wareham, Nicholas J.
Langenberg, Claudia
Source :
Nat Genet
Publication Year :
2021

Abstract

Circulating levels of small molecules or metabolites are highly heritable, but the impact of genetic differences in metabolism on human health is not well understood. In this cross-platform, genome-wide meta-analysis of 174 metabolite levels across six cohorts including up to 86,507 participants (70% unpublished data), we identify 499 (362 novel) genome-wide significant associations (p

Details

Language :
English
ISSN :
17345286
Database :
OpenAIRE
Journal :
Nat Genet
Accession number :
edsair.pmid..........0d1c44c718999820a0ae08de305fe80e