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Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes
- Source :
- Nat Genet
- Publication Year :
- 2021
-
Abstract
- Circulating levels of small molecules or metabolites are highly heritable, but the impact of genetic differences in metabolism on human health is not well understood. In this cross-platform, genome-wide meta-analysis of 174 metabolite levels across six cohorts including up to 86,507 participants (70% unpublished data), we identify 499 (362 novel) genome-wide significant associations (p
- Subjects :
- Eye Diseases
Genome, Human
Glycine
Mutation, Missense
Genetic Pleiotropy
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
Article
Metabolism
Phenotype
Diabetes Mellitus, Type 2
Gene Frequency
Genetic Loci
Health
Sample Size
Glucagon-Like Peptide-2 Receptor
Linear Models
Metabolome
Serine
Humans
Retinal Telangiectasis
Metabolism, Inborn Errors
Subjects
Details
- Language :
- English
- ISSN :
- 17345286
- Database :
- OpenAIRE
- Journal :
- Nat Genet
- Accession number :
- edsair.pmid..........0d1c44c718999820a0ae08de305fe80e