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Delta-like ligand 4 (Dll4) predicts the prognosis of clear cell renal cell carcinoma, and anti-Dll4 suppresses tumor growth in vivo
- Source :
- International journal of clinical and experimental pathology. 7(5)
- Publication Year :
- 2014
-
Abstract
- The Delta-like ligand 4 (Dll4) and Notch signaling pathway plays a key role in embryonic vascular development and tumor growth. In this study, we measured the expression of Dll4 in clear cell renal cell carcinoma (ccRCC) and explored the correlation between Dll4 and ccRCC. We used sh-Dll4 treatment in a nude mouse model to observe the effect that inhibition of the Dll4/Notch pathway had on angiogenesis and vasculogenesis. We found up-regulation of Dll4 to be closely correlated with distant metastasis and worse overall survival. Cox regression analysis showed that Dll4 might be a prognostic marker of ccRCC. Blockade of Dll4/Notch signaling inhibited tumor growth in the mouse model via anti-angiogenesis and anti-vasculogenesis effects. We concluded that Dll4 might be a novel therapeutic target for the treatment of ccRCC.
- Subjects :
- Male
Time Factors
Mice, Nude
Risk Factors
Cell Line, Tumor
Biomarkers, Tumor
Animals
Humans
RNA, Small Interfering
Carcinoma, Renal Cell
Adaptor Proteins, Signal Transducing
Aged
Cell Proliferation
Proportional Hazards Models
Neovascularization, Pathologic
Calcium-Binding Proteins
Genetic Therapy
Middle Aged
Xenograft Model Antitumor Assays
Kidney Neoplasms
Tumor Burden
Gene Expression Regulation, Neoplastic
cardiovascular system
Intercellular Signaling Peptides and Proteins
Female
RNA Interference
Original Article
Subjects
Details
- ISSN :
- 19362625
- Volume :
- 7
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- International journal of clinical and experimental pathology
- Accession number :
- edsair.pmid..........0dd9312f826bbc555ad76bccfe74a36a