Prediction of outcome by

The purpose of this study was to assess the prognostic value of cardiacWe retrospectively evaluated 311 INOCA patients who underwent rest stressDuring a median follow-up of 37 months (range 6-108), 23 (7%) cardiac events occurred. In patients with events total perfusion defect (TPD) was higher and myocardial flow reserve (MFR) lower compared to those without events (both P .001). At multivariable Cox analysis, increased TPD (i.e., ≥ 5%) and reduced MFR (i.e., 2) were predictors of events (both P .001). At Weibull survival analysis, the highest probability of cardiac events and risk acceleration were observed in patients with both increased TPD and reduced MFR. Annualized event rate was higher in patients with reduced MFR compared to those with preserved MFR (P .001).In patients with INOCA, the combined evaluation of myocardial perfusion and coronary vascular function by