Imaging Autotaxin

Authors :: Xiaoyun, Deng
Fernando, Salgado-Polo
Tuo, Shao
Zhiwei, Xiao
Richard, Van
Jiahui, Chen
Jian, Rong
Ahmed, Haider
Yihan, Shao
Lee, Josephson
Anastassis, Perrakis
Steven H, Liang
Source :: Journal of medicinal chemistry. 64(20)
Publication Year :: 2021
Abstract: Autotaxin (ATX) is a secreted phosphodiesterase that has been implicated in a remarkably wide array of pathologies, especially in fibrosis and cancer. While ATX inhibitors have entered the clinical arena, a validated probe for positron emission tomography (PET) is currently lacking. With the aim to develop a suitable ATX-targeted PET radioligand, we have synthesized a focused library of fluorinated imidazo[1,2