Altered interactions among resting state networks in obese individuals

OBJECTIVE: To investigate alterations in functional-connectivity (FC) within and interactions between resting-state-networks (RSNs) involved in salience, executive-control and interoception in subjects with obesity (OB). METHODS: Using RS-fMRI with independent-component-analysis and FC, we investigated alterations within and interactions between RSNs in 35 OB and 35 normal-weight (NW) controls. RESULTS: Compared to NW, OB showed reduced FC strength in the ventromedial prefrontal cortex (VMPFC) and posterior cingulate cortex (PCC)/precuneus within the default-mode network (DMN), dorsal anterior cingulate cortex (dACC) within the salience network (SN), bilateral dorsolateral prefrontal cortex (DLPFC)/angular gyrus (ANG) within the frontoparietal network (FPN), and increased FC strength in the insula (INS, P(FWE)