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Real-world evidence of the management and prognosis of young women (⩽40 years) with
Real-world evidence of the management and prognosis of young women (⩽40 years) with
- Source :
- Therapeutic Advances in Medical Oncology
- Publication Year :
- 2021
-
Abstract
- Background: Breast cancer (BC) in young women merits a specific approach given the associated fertility, genetic and psychosocial issues. De novo metastatic breast cancer (MBC) in young women is an even more serious condition, with limited data available. Methods: We evaluated management of women aged ⩽40 years with de novo MBC in a real-life national multicentre cohort of 22,463 patients treated between 2008 and 2016 (NCT0327531). Our primary objective was to compare overall survival (OS) in young women versus women aged 41–69 years. The secondary objectives were to compare first-line progression-free survival (PFS1) and to describe treatment patterns. Results: Of the 4524 women included, 598 (13%) were ⩽40 years. Median age at MBC diagnosis was 36 years (range = 20–40). Compared with women aged 41–69 years, young women had more grade III tumours (49% versus 35.7%, p
- Subjects :
- de novo
young women
metastatic breast cancer
prognosis
real-life
Original Research
Subjects
Details
- ISSN :
- 17588340
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Therapeutic advances in medical oncology
- Accession number :
- edsair.pmid..........15fcc26bdb5b4ec174fb59304ef9b90e