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Real-world evidence of the management and prognosis of young women (⩽40 years) with

Real-world evidence of the management and prognosis of young women (⩽40 years) with

Authors :
Amélie, Mallet
Amélie, Lusque
Christelle, Levy
Barbara, Pistilli
Etienne, Brain
David, Pasquier
Marc, Debled
Jean Christophe, Thery
Anthony, Gonçalves
Isabelle, Desmoulins
Thibault, De La Motte Rouge
Christelle, Faure
Jean Marc, Ferrero
Jean Christophe, Eymard
Marie Ange, Mouret-Reynier
Anne, Patsouris
Paul, Cottu
Florence, Dalenc
Thierry, Petit
Olivier, Payen
Lionel, Uwer
Séverine, Guiu
Jean Sébastien, Frenel
Source :
Therapeutic Advances in Medical Oncology
Publication Year :
2021

Abstract

Background: Breast cancer (BC) in young women merits a specific approach given the associated fertility, genetic and psychosocial issues. De novo metastatic breast cancer (MBC) in young women is an even more serious condition, with limited data available. Methods: We evaluated management of women aged ⩽40 years with de novo MBC in a real-life national multicentre cohort of 22,463 patients treated between 2008 and 2016 (NCT0327531). Our primary objective was to compare overall survival (OS) in young women versus women aged 41–69 years. The secondary objectives were to compare first-line progression-free survival (PFS1) and to describe treatment patterns. Results: Of the 4524 women included, 598 (13%) were ⩽40 years. Median age at MBC diagnosis was 36 years (range = 20–40). Compared with women aged 41–69 years, young women had more grade III tumours (49% versus 35.7%, p

Details

ISSN :
17588340
Volume :
14
Database :
OpenAIRE
Journal :
Therapeutic advances in medical oncology
Accession number :
edsair.pmid..........15fcc26bdb5b4ec174fb59304ef9b90e