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Insights into the role of cell-cell junctions in physiology and disease
- Source :
- International review of cell and molecular biology. 306
- Publication Year :
- 2013
-
Abstract
- Contacting cells establish different classes of intricate structures at the cell-cell junctions. These structures are of increasing research interest as they regulate a broad variety of processes in development and disease. Further, in vitro studies are revealing that various cell-cell interaction proteins are involved not only in cell-cell processes but also in many additional aspects of physiology, such as migration and apoptosis. This chapter reviews the basic classification of cell-cell junctional structures and some of their representative proteins. Their roles in development and disease are briefly outlined, followed by a section on contemporary methods for probing cell-cell interactions and some recent developments. This chapter concludes with a few suggestions for potential research directions to further develop this promising area of study.
- Subjects :
- Intercellular Junctions
Animals
Humans
Disease
Subjects
Details
- ISSN :
- 19376448
- Volume :
- 306
- Database :
- OpenAIRE
- Journal :
- International review of cell and molecular biology
- Accession number :
- edsair.pmid..........163f3d93724094bb5b9fb5de18dc6833