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[Management of gestational trophoblastic disease]
[Management of gestational trophoblastic disease]
- Source :
- Gynecologie, obstetriquefertilite. 38(3)
- Publication Year :
- 2010
-
Abstract
- Gestational trophoblastic diseases comprise of hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor. Most of those pathologies are chemosensitive and have excellent prognosis, allowing preserving women's fertility because of the low relapse rate during further pregnancies. Physiopathological mechanisms and risk factors are now better understood. Hydatiform moles have to be treated by suction rather than curettage. Placental site trophoblastic tumors are particular chemoresistant pathologies, not secreting hCG which needs specific management. Trophoblastic tumors can be divided into two groups: a low risk group treated by monotherapy, most often by Methotrexate or actinomycine D, with survey about 100% and a high risk group treated by polychemotherapy (Etoposide, Methotrexate, actinomycine D, cyclophosphamide, Vincristine with survey of 86%. Chemorefractarory patients keep deep prognosis with 5 years survival rate of 43%, which allow development of new therapy in this indication. Measurement of hCG remains today central for supervision. A specialised management by an experimented team is essential to give patients better chance of recovery.
- Subjects :
- Adult
Antineoplastic Agents
Hydatidiform Mole
Suction
Prognosis
Chorionic Gonadotropin
Trophoblastic Tumor, Placental Site
Drug Resistance, Neoplasm
Pregnancy
Risk Factors
Antineoplastic Combined Chemotherapy Protocols
Uterine Neoplasms
Humans
Female
Choriocarcinoma
Gestational Trophoblastic Disease
Subjects
Details
- Language :
- French
- ISSN :
- 17696682
- Volume :
- 38
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Gynecologie, obstetriquefertilite
- Accession number :
- edsair.pmid..........19ed29c69d1fe9686a8a4188b2638a94