Synthesis, biological evaluation and molecular modelling studies of 1,3,7,8-tetrasubstituted xanthines as potent and selective A

Authors :: Suman, Rohilla
Ranju, Bansal
Sonja, Kachler
Karl-Norbert, Klotz
Source :: Bioorganic chemistry. 87
Publication Year :: 2018
Abstract: In the present study, an attempt has been made to develop a new series of 1,3,7,8-tetrasubstituted xanthine based potent and selective AR ligands for the treatment of Parkinson's disease. Antagonistic interactions between dopamine and A

Subjects :: Antiparkinson Agents
Models, Molecular
Disease Models, Animal
Molecular Structure
Receptor, Adenosine A2A
Xanthines
Animals
Parkinson Disease
Ligands
Cells, Cultured
Adenosine A2 Receptor Antagonists
Rats

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