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Activating STING1-dependent immune signaling in
- Source :
- Proceedings of the National Academy of Sciences of the United States of America. 119(27)
- Publication Year :
- 2022
-
Abstract
- DNA methyltransferase inhibitors (DNMTis) reexpress hypermethylated genes in cancers and leukemias and also activate endogenous retroviruses (ERVs), leading to interferon (IFN) signaling, in a process known as viral mimicry. In the present study we show that in the subset of acute myeloid leukemias (AMLs) with mutations in
Details
- ISSN :
- 10916490
- Volume :
- 119
- Issue :
- 27
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Accession number :
- edsair.pmid..........1e9eb5472bcd643d961fbe3cc3ba2051