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Synthesis and Evaluation of Thiazolidine Amide and N-Thiazolyl Amide Fluoroquinolone Derivatives
- Source :
- Archiv der Pharmazie. 350(6)
- Publication Year :
- 2017
-
Abstract
- In an effort to develop new fluoroquinolones, we synthesized eight compounds and tested them against a panel of bacteria. The design of these compounds was guided by the introduction of the isothiazoloquinolone motif. The three most active compounds in this series, 8-10, demonstrated good antibacterial activity against methicillin-sensitive Staphylococcus aureus and healthcare-acquired methicillin-resistant Staphylococcus aureus (MIC 0.62-6.3 µg/mL). Further, when these three active compounds were tested for their inhibitory effects on bacterial enzymes, compound 9 was the most effective agent exhibiting IC
Details
- ISSN :
- 15214184
- Volume :
- 350
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Archiv der Pharmazie
- Accession number :
- edsair.pmid..........1fa479ea0fe79c3c8cb979c6c5a76966