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A mechanism for oxidative damage repair at gene regulatory elements

Authors :
Swagat, Ray
Arwa A, Abugable
Jacob, Parker
Kirsty, Liversidge
Nelma M, Palminha
Chunyan, Liao
Adelina E, Acosta-Martin
Cleide D S, Souza
Mateusz, Jurga
Ian, Sudbery
Sherif F, El-Khamisy
Source :
Nature. 609(7929)
Publication Year :
2020

Abstract

Oxidative genome damage is an unavoidable consequence of cellular metabolism. It arises at gene regulatory elements by epigenetic demethylation during transcriptional activation

Subjects

Subjects :
DNA Repair
Phosphoric Diester Hydrolases
Genetic Complementation Test
Mitosis
Cell Cycle Proteins
Spindle Apparatus
Chromatin
Oxidative Stress
Poly ADP Ribosylation
Genes
Mutation
RNA
RNA Polymerase II
Transcription Initiation Site
Promoter Regions, Genetic
DNA Damage

Details

ISSN :
14764687
Volume :
609
Issue :
7929
Database :
OpenAIRE
Journal :
Nature
Accession number :
edsair.pmid..........253a0f1af9ec07479f091b8573150f73

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Authors Abstract Subjects Details