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Preparation of five 3-MCPD fatty acid esters, and the effects of their chemical structures on acute oral toxicity in Swiss mice
- Source :
- Journal of the science of food and agriculture. 97(3)
- Publication Year :
- 2015
-
Abstract
- 3-monochloro-1, 2-propanediol fatty acid esters (3-MCPDEs) comprise a group of food toxicants formed during food processing. 3-MCPDEs have received increasing attention concerning their potential negative effects on human health. However, reports on the toxicity of 3-MCPD esters are still limited. To determine the effects of fatty acid substitutions on the toxicity of their esters, 1-stearic, 1-oleic, 1-linoleic, 1-linoleic-2-palmitic and 1-palmitic-2-linoleic acid esters of 3-MCPD were synthesized and evaluated with respect to their acute oral toxicities in Swiss mice.3-MCPDEs were obtained through the reaction of 3-MCPD and fatty acid chlorides, and their purities and structures were characterized by ultraperformance liquid chromatography-quadrupole-time of flight-mass spectrometry (UPLC-Q-TOF-MS), infrared,The results from the present study suggest that the degree of unsaturation, chain length, number of substitution and relative substitution locations of fatty acids might alter the toxicity of 3-MCPDEs. © 2016 Society of Chemical Industry.
- Subjects :
- Male
Neurons
Behavior, Animal
Molecular Structure
Food Handling
Brain
Food Contamination
Organ Size
Thymus Gland
Diglycerides
Lethal Dose 50
Mice
Random Allocation
Structure-Activity Relationship
Liver
Hydrocarbons, Chlorinated
Toxicity Tests, Acute
Animals
Monoglycerides
Female
Neurotoxicity Syndromes
Subjects
Details
- ISSN :
- 10970010
- Volume :
- 97
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of the science of food and agriculture
- Accession number :
- edsair.pmid..........2655d91a47a541a149076d836812761a