MODULATION OF CARCINOGEN-METABOLIZING ENZYME BY MADINAH MINT (

Background: The present study was undertaken to assess whether boiling water mint extract (BWME) modulates the cytochrome P450 mixed function oxidase system. Materials and methods: Male albino rats were randomly divided into two groups, comprising 12 animals each. The first group served as control, whereas the second was maintained on BWME (10 % w/v) as its sole drinking liquid for six weeks. Liver microsomal were separated and subjected for phase I and II enzymes (cytochrome P450 mixed function oxidase) analysis Results: The results obtained showed that, BWME caused a significant elevation in the activity of epoxide hydrolase (p