Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A

Authors :: Wenzhong, Yan
Lijun, Ling
Yiran, Wu
Kexin, Yang
Ruiquan, Liu
Jinfeng, Zhang
Simeng, Zhao
Guisheng, Zhong
Suwen, Zhao
Hualiang, Jiang
Chengying, Xie
Jianjun, Cheng
Source :: Journal of medicinal chemistry. 64(22)
Publication Year :: 2021
Abstract: Adenosine is an immunosuppressive factor in the tumor microenvironment mainly through activation of the A

Subjects :: Histone Deacetylase Inhibitors
Immunosuppression Therapy
Mice
Structure-Activity Relationship
Adenosine A2 Receptor Agonists
Receptor, Adenosine A2A
Drug Design
Animals
Humans
Antineoplastic Agents
Proof of Concept Study
Immunosuppressive Agents

Tools