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Maternal Allopurinol Prevents Cardiac Dysfunction in Adult Male Offspring Programmed by Chronic Hypoxia During Pregnancy
- Source :
- Hypertension (Dallas, Tex. : 1979). 72(4)
- Publication Year :
- 2018
-
Abstract
- Integrating functional and molecular levels, we investigated the effects of maternal treatment with a xanthine oxidase inhibitor on the programming of cardiac dysfunction in adult offspring using an established rat model of hypoxic pregnancy. Female Wistar rats were divided into normoxic or hypoxic (13% O
- Subjects :
- Heart Failure
Male
Receptor, Muscarinic M2
Xanthine Oxidase
Sympathetic Nervous System
Allopurinol
Myocardial Contraction
Rats
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Pregnancy Complications
Oxidative Stress
Pregnancy
Heart Function Tests
Receptors, Adrenergic, beta
Animals
Female
Enzyme Inhibitors
Hypoxia
Subjects
Details
- ISSN :
- 15244563
- Volume :
- 72
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Hypertension (Dallas, Tex. : 1979)
- Accession number :
- edsair.pmid..........29d9326511716c5ec3e6235d6c693cba