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[Management of patients developing acute gastro-intestinal graft-versus-host-disease: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)]

Authors :
Eva, de Berranger
Amandine, Charbonnier
Elise, Davy
Caroline, Dendonker
Virginie, Denis
Déborah, Desmier
Carole, Farrugia
Sarah, Guenounou
Yoann, Guilbert
Edgar, Jost
Alexandra, L'hostette
Fanny, Rialland
Sophie, Taque
Nabil, Yafour
David, Seguy
Ibrahim, Yakoub Agha
Source :
Bulletin du cancer. 108(12S)
Publication Year :
2020

Abstract

Graft-versus-host disease (GVHD) is the most common complication after allogeneic hematopoietic cell transplantation (allo-HCT) with a frequency range of 30% to 50%. GVH is the leading cause of non-relapse-related deaths and a cause early mortality. Gastro-intestinal (GI) GVH results in digestive manifestations that involve the small intestine and the colon. The patient may then have diarrhea, intestinal bleeding, abdominal pain but also clinical signs such as nausea and vomiting may lead to anorexia. GI-GVHD promotes undernutrition as well as significant losses of vitamins and trace elements. In the case of post-transplant diarrhea, differential diagnosis can include GI-GVHD, infection and drug toxicity. Although, corticosteroids w/wo calcineurin inhibitors represent the standard of care in first line treatment, there is no consensus regarding salvage therapy in case of corticoresistant GI-GVH. In addition, assessment of early nutritional status would help combating undernutrition, which is an independent risk factor for mortality in patients with GI-GVHD. In this workshop of the Fancophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) we focused on the management of patients developing GI-GVHD following allo-HCT.

Details

Language :
French
ISSN :
17696917
Volume :
108
Issue :
12S
Database :
OpenAIRE
Journal :
Bulletin du cancer
Accession number :
edsair.pmid..........2a39386a2753c267b30d60a656eb10e0