Identification of Senescent Cells in the Bone Microenvironment

Authors :: Joshua N, Farr
Daniel G, Fraser
Haitao, Wang
Katharina, Jaehn
Mikolaj B, Ogrodnik
Megan M, Weivoda
Matthew T, Drake
Tamara, Tchkonia
Nathan K, LeBrasseur
James L, Kirkland
Lynda F, Bonewald
Robert J, Pignolo
David G, Monroe
Sundeep, Khosla
Source :: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 31(11)
Publication Year :: 2016
Abstract: Cellular senescence is a fundamental mechanism by which cells remain metabolically active yet cease dividing and undergo distinct phenotypic alterations, including upregulation of p16

Subjects :: Male
Osteoblasts
DNA, Satellite
Osteocytes
Bone and Bones
Mice, Inbred C57BL
Phenotype
Cellular Microenvironment
Animals
Cell Lineage
Female
Myeloid Cells
Biomarkers
Cells, Cultured
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p16

ISSN :: 15234681
Volume :: 31
Issue :: 11
Database :: OpenAIRE
Journal :: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Accession number :: edsair.pmid..........2c594d914b58f5c8021b30fb59d45e00

Tools