Visualizing Sphingosine-1-Phosphate Receptor 1(S1P

Authors :: Ezzat, Hashemi
Ezra, Yoseph
Hsing-Chuan, Tsai
Monica, Moreno
Li-Hao, Yeh
Shalin B, Mehta
Mari, Kono
Richard, Proia
May H, Han
Source :: Cellular and molecular neurobiology.
Publication Year :: 2021
Abstract: Multiple sclerosis (MS) is an inflammatory-demyelinating disease of the central nervous system (CNS) mediated by aberrant auto-reactive immune responses. The current immune-modulatory therapies are unable to protect and repair immune-mediated neural tissue damage. One of the therapeutic targets in MS is the sphingosine-1-phosphate (S1P) pathway which signals via sphingosine-1-phosphate receptors 1-5 (S1P

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