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3-year results of docetaxel-based sequential and combination regimens in the adjuvant therapy of node-positive breast cancer: a pilot study
- Source :
- Anticancer research. 22(4)
- Publication Year :
- 2002
-
Abstract
- Docetaxel has proven efficacy in metastatic breast cancer. In this pilot study, we explored the efficacy/feasibility of docetaxel-based sequential and combination regimens as adjuvant therapy of node-positive breast cancer.From March 1996 till March 1998, four consecutive groups of patients with stages II and III breast cancer, agedor = 70 years, received one of the following regimens: a) sequential Doxorubicin (A) --Docetaxel (T) --CMF (Cyclophosphamide+Methotrexate+5-Fluorouracil): A 75 mg/m q 3 wks x 3, followed by T100 mg/m2 q 3 wks x 3, followed by i.v. CMF Days 1+8 q 4 wks x 3; b) sequential accelerated A --T --CMF: A and T administered at the same doses q 2 wks with Lenograstin support; c) combination therapy: A 50 mg/m2 + T 75 mg/m2 q 3 wks x 4, followed by CMF x 4; d) sequential T --A --CMF: T and A, administered as in group a), with the reverse sequence. When indicated, radiotherapy was administered during or after CMF, and Tamoxifen after CMF.Ninety-three patients were treated. The median age was 48 years (29-66) and the median number of positive axillary nodes was 6 (1-25). Tumors were operable in 94% and locally advanced in 6% of cases. Pathological tumor size was2 cm in 72% of cases. There were 21 relapses, (18 systemic, 3 locoregional) and 11 patients (12%) have died from disease progression. At median follow-up of 39 months (6-57), overall survival (OS) was 87% (95% CI, 79-94%) and disease-free survival (DFS) was 76% (95% CI, 67%-85%).The efficacy of these docetaxel-based regimens, in terms of OS and DFS, appears to be at least as good as standard anthracycline-based adjuvant chemotherapy (CT), in similar high-risk patient populations.
- Subjects :
- Time Factors
Adolescent
Paclitaxel
Breast Neoplasms
Pilot Projects
Docetaxel
Middle Aged
Antineoplastic Agents, Phytogenic
Disease-Free Survival
Survival Rate
Tamoxifen
Methotrexate
Treatment Outcome
Chemotherapy, Adjuvant
Doxorubicin
Lymphatic Metastasis
Antineoplastic Combined Chemotherapy Protocols
Humans
Female
Taxoids
Fluorouracil
Cisplatin
Aged
Phytotherapy
Subjects
Details
- ISSN :
- 02507005
- Volume :
- 22
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Anticancer research
- Accession number :
- edsair.pmid..........320920a4fe35a401782a8ff5cdd80ce2