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High-dose chemotherapy with bone marrow transplantation for advanced colorectal cancer
- Source :
- International journal of oncology. 11(1)
- Publication Year :
- 2011
-
Abstract
- A chemotherapy regimen based on high doses of BCNU and mitomycin C with autologous bone marrow transplantation was used in 18 patients with advanced colorectal carcinoma. Haematological toxicity was manageable, with a short nadir for white blood cells and platelets. The response rate was 33%, with a prevalence in peritoneal lesions compared to liver or lung metastases. Extra-haematological toxicity appeared in 16% of cases: a case of veno-occlusive disease of the liver and two cases of lung impairment are discussed. Although the response rate obtained with the regimen was satisfactory, the more extensive use of high-dose chemotherapy followed by autologous bone marrow transplantation requires the identification of less toxic protocols.
Details
- ISSN :
- 10196439
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of oncology
- Accession number :
- edsair.pmid..........321844f4fc02bd8e5c05d821c778d526