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Pt(IV)-Deferasirox Prodrug Combats DNA Damage Repair by Regulating RNA N

Authors :
Zheng-Yin, Pan
Yu-Yi, Ling
Hang, Zhang
Liang, Hao
Cai-Ping, Tan
Zong-Wan, Mao
Source :
Journal of medicinal chemistry. 65(21)
Publication Year :
2022

Abstract

DNA damage repair is considered to be an important mechanism of cisplatin resistance, and the roles of iron homeostasis in action mechanisms of cisplatin have not been studied yet. Herein, a Pt(IV) prodrug (

Details

ISSN :
15204804
Volume :
65
Issue :
21
Database :
OpenAIRE
Journal :
Journal of medicinal chemistry
Accession number :
edsair.pmid..........32476b5f49ea4b6949a0fae027819e5e