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Molecular alterations induced by hypertension in pregnancy on syncythiotrophoblast plasma membranes from human placenta
Molecular alterations induced by hypertension in pregnancy on syncythiotrophoblast plasma membranes from human placenta
- Source :
- Biochemistry international. 19(6)
- Publication Year :
- 1989
-
Abstract
- To evaluate the possible functional relationships between hypertensive status and syncythiotrophoblast plasma membrane behaviour we have carried out a freeze-fracturing and biochemical investigation to assess: 1) ultrastructurally, relations between number and diameter of Intramembrane Particles (IMP) and hypertensive conditions; 2) biochemically, actin content of microvilli in this pathological status. Our data in vitro show a decrease of IMP in hypertension before and after Ca++ addition and a decrease of actin in microvilli of hypertensive placenta. These observations seem to be in agreement with the hypothesis of a possible structural immaturity in hypertensive placenta and may represent morphological signs of placental insufficiency.
Details
- ISSN :
- 01585231
- Volume :
- 19
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Biochemistry international
- Accession number :
- edsair.pmid..........37086cc81c1bbd71758393e9d1c526bb