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Molecular alterations induced by hypertension in pregnancy on syncythiotrophoblast plasma membranes from human placenta

Molecular alterations induced by hypertension in pregnancy on syncythiotrophoblast plasma membranes from human placenta

Authors :
L, Mazzanti
A, Damadei
N, Cester
G, Benedetti
C, Romanini
G, Biagini
Source :
Biochemistry international. 19(6)
Publication Year :
1989

Abstract

To evaluate the possible functional relationships between hypertensive status and syncythiotrophoblast plasma membrane behaviour we have carried out a freeze-fracturing and biochemical investigation to assess: 1) ultrastructurally, relations between number and diameter of Intramembrane Particles (IMP) and hypertensive conditions; 2) biochemically, actin content of microvilli in this pathological status. Our data in vitro show a decrease of IMP in hypertension before and after Ca++ addition and a decrease of actin in microvilli of hypertensive placenta. These observations seem to be in agreement with the hypothesis of a possible structural immaturity in hypertensive placenta and may represent morphological signs of placental insufficiency.

Details

ISSN :
01585231
Volume :
19
Issue :
6
Database :
OpenAIRE
Journal :
Biochemistry international
Accession number :
edsair.pmid..........37086cc81c1bbd71758393e9d1c526bb