Involution of Neovascular Age-Related Macular Degeneration Following Endophthalmitis

PURPOSE: To report patients who demonstrated an alteration in the clinical and optical coherence tomography (OCT) features of neovascular age-related macular degeneration (AMD) following resolution of endophthalmitis. METHODS: Retrospective case series of the subsequent changes in the macula and need for anti-VEGF therapy in patients with neovascular AMD who developed endophthalmitis following intravitreal injection. RESULTS: The study included 7 eyes of 7 patients with follow-up ranging between 3 months and 11 years. The vitreous cultures (n=7) prior to intravitreal antibiotic injection were the following: culture negative (4) and coagulase-negative Staphylococcus (3). Initial treatment included vitreous tap and injection (4) and pars plana vitrectomy (PPV, 3). In 5/7 eyes, the OCT showed resolution of subretinal fluid and serous pigment epithelial detachment and there was no additional anti-VEGF treatment administered. CONCLUSION: After successful treatment of endophthalmitis in patients with neovascular AMD, there was relative involution of the maculopathy and reduced anti-VEGF treatment burden in this series.