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MiR-507 inhibits the growth and invasion of trophoblasts by targeting CAMK4
- Source :
- European review for medical and pharmacological sciences. 24(11)
- Publication Year :
- 2020
-
Abstract
- To elucidate the potential influences of miR-507 and CAMK4 on the progression of preeclampsia (PE).Placental tissues were collected from 24 PE pregnancies and 24 healthy pregnancies. The relative levels of miR-507 and CAMK4 in placental tissues were detected. In addition, expressions of apoptosis-associated genes in collected tissues were examined by both quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA). The influences of miR-507 and CAMK4 on proliferative and migratory abilities in HTR-8/SVneo cells were assessed by CCK-8 and transwell assay, respectively. The target relationship between miR-507 and CAMK4 was detected by Luciferase assay.MiR-507 was upregulated in placental tissues collected from PE pregnancies. Overexpression of miR-507 suppressed proliferative and migratory abilities, and stimulated apoptosis in HTR-8/SVneo cells. CAMK4 was the target gene of miR-507, which was downregulated in placental tissues collected from PE pregnancies and negatively correlated to miR-507 level. The knockdown of CAMK4 suppressed proliferative and migratory abilities, and stimulated apoptosis in HTR-8/SVneo cells, and these trends were abolished by silence of miR-507.Highly expressed miR-507 in PE pregnancies inhibits proliferative and migratory potentials, and induces apoptosis in trophoblasts by targeting CAMK4.
Details
- ISSN :
- 22840729
- Volume :
- 24
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- European review for medical and pharmacological sciences
- Accession number :
- edsair.pmid..........3b62f4bfca534c1e8fc350031a61dffc