Prolonged survival of kidney xenografts in leucopenic rabbits

Rabbits rendered leucopenic by means of nitrogen mustard reject kidney xenografts more slowly than normal controls It is therefore probable that polymorphonuclear leucocytes play an important role in the acute rejection of xenografts. The previously reported complement requirement for xenograft rejection was also confirmed in this work, by depleting the graft recipients of C3 with cobra venom factor.