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Increased expression of the high-mannose
- Source :
- Oncology Letters
- Publication Year :
- 2016
-
Abstract
- Changes in protein glycosylation have been reported in various types of cancer, including cholangiocarcinoma (CCA). Nanospray ionization-linear ion trap mass spectrometry (NSI-MSn) was used in the present study to determine the comparative structural glycomics of the N-linked glycans in the serum of patients with CCA compared with healthy controls. A total of 5 high-mannose and 4 complex N-linked glycans were detected. Mannose7-N-acetyl-glucosamine2 was the most abundant structure among the high-mannose types (control 12.12±2.54 vs. CCA 9.27±2.66%), whereas NeuAc2H2N2M3N2 predominated the complex types (control 61.17±2.55 vs. CCA 64.68±4.23%). The expression of 3 different N-glycans differed significantly between the CCA cases and controls. These included mannose6-N-acetyl-glucosamine2 (P=0.044), mannose9-N-acetyl-glucosamine2 (Ρ=0.030) and NeuAc3H3N3M3N2F (Ρ=0.002). These three glycan structures may therefore be associated with tumor progression in CCA and may be useful for its diagnosis.
- Subjects :
- high-mannose N-glycans
Articles
cholangiocarcinoma
Tri-antennary N-glycans
Subjects
Details
- ISSN :
- 17921074
- Volume :
- 15
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Oncology letters
- Accession number :
- edsair.pmid..........42eced9b1b0037c8e710b2353bf0b84b