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Identifying the lifetime cognitive and socioeconomic antecedents of cognitive state: seven decades of follow-up in a British birth cohort study
- Source :
- BMJ Open
- Publication Year :
- 2019
-
Abstract
- Objectives The life course determinants of midlife and later life cognitive function have been studied using longitudinal population-based cohort data, but far less is known about whether the pattern of these pathways is similar or distinct for clinically relevant cognitive state. We investigated this for Addenbrooke’s Cognitive Examination third edition (ACE-III), used in clinical settings to screen for cognitive impairment and dementia. Design Longitudinal birth cohort study. Setting Residential addresses in England, Wales and Scotland. Participants 1762 community-dwelling men and women of European heritage, enrolled since birth in the Medical Research Council (MRC) National Survey of Health and Development (the British 1946 birth cohort). Primary outcome ACE-III. Results Path modelling estimated direct and indirect associations between apolipoprotein E (APOE) status, father’s social class, childhood cognition, education, midlife occupational complexity, midlife verbal ability (National Adult Reading Test; NART), and the total ACE-III score. Controlling for sex, there was a direct negative association between APOE ε4 and the ACE-III score (β=−0.04 [–0.08 to –0.002], p=0.04), but not between APOE ε4 and childhood cognition (β=0.03 [–0.006 to 0.069], p=0.10) or the NART (β=0.0005 [–0.03 to 0.03], p=0.97). The strongest influences on the ACE-III were from childhood cognition (β=0.20 [0.14 to 0.26], p
- Subjects :
- Adult
Male
Aging
Adolescent
Epidemiology
Apolipoprotein E4
White People
Cohort Studies
Young Adult
Child Development
Cognition
Memory
old age psychiatry
Humans
Longitudinal Studies
Occupations
Child
Aged
Wales
Research
Wechsler Scales
Middle Aged
Health Surveys
England
Scotland
Social Class
Language Arts
Educational Status
Dementia
Female
Cognition Disorders
Follow-Up Studies
Subjects
Details
- ISSN :
- 20446055
- Volume :
- 9
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- BMJ open
- Accession number :
- edsair.pmid..........432e9ff00ca660ecf84f72e3530f9b84