Rapid improvement of calcinosis in juvenile dermatomyositis with alendronate therapy

Authors :: Geoffrey R, Ambler
Jeffrey, Chaitow
Maureen, Rogers
David W, McDonald
Robert A, Ouvrier
Source :: The Journal of rheumatology. 32(9)
Publication Year :: 2005
Abstract: A 6-year-old boy with improving juvenile dermatomyositis (JDM) developed severe and debilitating calcinosis, unresponsive to diltiazem and probenecid. Alendronate produced dramatic improvement within 1 month and by 12 months calcinosis had virtually resolved. The response was followed by bone mineral content measurements.

Subjects :: Male
Alendronate
Dose-Response Relationship, Drug
Calcinosis
Risk Assessment
Severity of Illness Index
Dermatomyositis
Drug Administration Schedule
Radiography
Methotrexate
Treatment Outcome
Humans
Prednisone
Drug Therapy, Combination
Child
Follow-Up Studies

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