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Immune disease risk variants regulate gene expression dynamics during CD4
- Source :
- Nature genetics. 54(6)
- Publication Year :
- 2021
-
Abstract
- During activation, T cells undergo extensive gene expression changes that shape the properties of cells to exert their effector function. Understanding the regulation of this process could help explain how genetic variants predispose to immune diseases. Here, we mapped genetic effects on gene expression (expression quantitative trait loci (eQTLs)) using single-cell transcriptomics. We profiled 655,349 CD4
Details
- ISSN :
- 15461718
- Volume :
- 54
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Nature genetics
- Accession number :
- edsair.pmid..........46860c214c976dd24d59d5609ff22ff9