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Short Communication: Characterization of Cellular Immune Responses in Thai Individuals With and Without HIV-Associated Neurocognitive Disorders
- Publication Year :
- 2018
- Publisher :
- Mary Ann Liebert, Inc., 2018.
-
Abstract
- HIV-associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8(+) T cell activation (HLA-DR(+)/CD38(+)) and HIV-specific CD8(+) T cell responses at the time of HIV diagnosis and 12 months postinitiation of ART. CD8(+) T cell activation was increased in HAND compared to cognitive normal (NL) individuals and correlated directly with plasma viral load and inversely with the cognitive status. In addition, Gag-specific cytolytic activity (CD107a/b(+)) was decreased in HAND compared with NL individuals and correlated with their neurological testing, suggesting a potential role of cytotoxic CD8(+) T cells in the mechanism of HAND development.
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.pmid..........47470cf75abf5004a5bca570b24fea0a