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Defibrotide for the treatment of PIMS-TS in two pediatric patients
- Source :
- Journal of the Pediatric Infectious Diseases Society
- Publication Year :
- 2020
- Publisher :
- Oxford University Press, 2020.
-
Abstract
- The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, we treated 2 patients with defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved during treatment. Moreover, coagulation parameters indicating hypofibrinolysis and complement activation normalized. The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, 2 patients received defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved and hypofibrinolysis/complement activation normalized during treatment.
- Subjects :
- Adolescent
Fever
SARS-CoV-2
Brief Report
T-Lymphocytes
Pneumonia, Viral
COVID-19
defibrotide
Blood Coagulation Factors
Systemic Inflammatory Response Syndrome
endotheliitis
Abdominal Pain
Betacoronavirus
AcademicSubjects/MED00290
Polydeoxyribonucleotides
children
Humans
complement
Female
AcademicSubjects/MED00670
Child
Coronavirus Infections
Pandemics
Platelet Aggregation Inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 20487207 and 20487193
- Database :
- OpenAIRE
- Journal :
- Journal of the Pediatric Infectious Diseases Society
- Accession number :
- edsair.pmid..........499b71f7dbff3a07f366552a67cc0307