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Is there a hypothalamic basis for anorexia nervosa?

Authors :
Virginie, Tolle
Nicolas, Ramoz
Jacques, Epelbaum
Source :
Handbook of clinical neurology. 181
Publication Year :
2021

Abstract

The hypothalamus has long been known to control food intake and energy metabolism through a complex network of primary and secondary neurons and glial cells. Anorexia nervosa being a complex disorder characterized by abnormal feeding behavior and food aversion, it is thus quite surprising that not much is known concerning potential hypothalamic modifications in this disorder. In this chapter, we review the recent advances in the fields of genetics, epigenetics, structural and functional imaging, and brain connectivity, as well as neuroendocrine findings and emerging animal models, which have begun to unravel the importance of hypothalamic adaptive processes to our understanding of the pathology of eating disorders.

Details

ISSN :
00729752
Volume :
181
Database :
OpenAIRE
Journal :
Handbook of clinical neurology
Accession number :
edsair.pmid..........4d1da2f64684726612a82f4de2b2e85d