Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X

Authors :: Shane M, Wilkinson
Melissa L, Barron
James, O'Brien-Brown
Bieneke, Janssen
Leanne, Stokes
Eryn L, Werry
Mansoor, Chishty
Kristen K, Skarratt
Jennifer A, Ong
David E, Hibbs
Danielle J, Vugts
Stephen, Fuller
Albert D, Windhorst
Michael, Kassiou
Source :: ACS chemical neuroscience. 8(11)
Publication Year :: 2017
Abstract: Adamantanyl benzamide 1 was identified as a potent P2X

Subjects :: Molecular Structure
Purinergic P2X Receptor Antagonists
Drug Evaluation, Preclinical
Adamantane
Polymorphism, Single Nucleotide
Rats
Structure-Activity Relationship
Drug Stability
Benzamides
Microsomes, Liver
Animals
Humans
Receptors, Purinergic P2X7
Oxidation-Reduction
Biotransformation

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